کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5905612 | 1159909 | 2015 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The influence of XRCC1 genetic variants on lung cancer susceptibility in Chinese Han population
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
SPSSXRCC1BERLEUHWECISSNPsgenetic variants - انواع ژنتیکیMolecular biomarkers - بیومارکرهای مولکولیHardy–Weinberg equilibrium - تعادل هاردی-وینبرگbase excision repair - تعمیر پایه پایهSusceptibility - حساسیتPCR-RFLP - روش PCR-RFLPLung cancer - سرطان ریهconfidence intervals - فاصله اطمینانPRO - نرم افزارodds ratios - نسبت شانسpolymerase chain reaction - واکنش زنجیره ای پلیمرازPCR - واکنش زنجیرهٔ پلیمرازSingle nucleotide polymorphisms - پلیمورفیسم تک نوکلئوتیدیpolymerase chain reaction-restriction fragment length polymorphism - پلیمورفیسم طول قطعه واکنش زنجیره پلیمراز
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
ژنتیک
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Growing evidence suggests that genetic variants of X-ray repair cross-complementing group 1 proteins (XRCC1) contribute to genetic effects on the development of lung cancer. This case-control study aims to evaluate the genetic effects of XRCC1 c.482C>T and c.1686C>G single nucleotide polymorphisms (SNPs) on lung cancer susceptibility. 391 lung cancer patients and 398 cancer-free controls were enrolled in this study. The genotypes of c.482C>T and c.1686C>G genetic variants were detected by the created restriction site-polymerase chain reaction (CRS-PCR), PCR-restriction fragment length polymorphism (PCR-RFLP) and DNA sequencing methods. The genetic effects on lung cancer susceptibility were evaluated using association analyses by the unconditional logistic regression model. Our data indicated that there were significant differences in the distribution of allelic and genotypic frequencies between lung cancer patients and cancer-free controls. The XRCC1 c.482C>T and c.1686C>G genetic variants were significantly associated with the susceptibility to lung cancer (for c.482C>T, TT versus (vs.) CC: ORÂ =Â 2.14, 95% CI 1.31-3.48, PÂ =Â 0.002; T vs. C: ORÂ =Â 1.37, 95% CI 1.10-1.69, PÂ =Â 0.004; for c.1686C>G, GG vs. CC: ORÂ =Â 2.53, 95% CI 1.46-4.38, PÂ =Â 0.001; G vs. C: ORÂ =Â 1.33, 95% CI 1.06-1.65, PÂ =Â 0.012). These preliminary results suggested that the XRCC1 c.482C>T and c.1686C>G genetic variants might play genetic effects on the susceptibility to lung cancer in the studied population.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gene - Volume 556, Issue 2, 10 February 2015, Pages 127-131
Journal: Gene - Volume 556, Issue 2, 10 February 2015, Pages 127-131
نویسندگان
Yingyi Wang, Jianjiao Ni, Zhao Sun, Shuchang Chen, Yuchen Jiao, Chunmei Bai,