Gene expression profiles displayed by peripheral blood mononuclear cells from patients with type 2 diabetes mellitus focusing on biological processes implicated on the pathogenesis of the disease

► PBMCs from T2DM patients present differential gene expression compared to controls. ► Induced genes are related to FA metabolism, protection against oxidative stress. ► Repressed genes are related to suppression of cytokines production, DNA repair. ► Two significant signaling pathways were identified: adipocytokine and ceramide. ► Patient features have no influence on expression profiles.