Oyster shell waste supported CuCl2 for aldehyde-alkyne-amine coupling reaction to propargylamines

The development of an economic and simple heterogeneous oyster shell waste supported CuCl2 catalyst for the aldehyde-alkyne-amine (A3) coupling reaction was reported. The waste oyster shell powder (OSP) supported CuCl2 (OSP-CuCl2) catalyst was prepared by a simple method from waste OSPs and CuCl2, which was shown to be a highly active and recyclable catalyst for the A3-coupling reaction. A range of propargylamines were obtained in good to excellent yields (85%–97%) under solvent-free and microwave-heated conditions. The OSP-CuCl2 catalyst can be simply recovered by filtration and reused for at least six runs. Propargylamine can be produced in 87% yield even when the scale of the A3-coupling reaction was increased to 150 mmol.

Graphical AbstractOSP-CuCl2 is a highly efficient, low cost and reusable catalyst for the synthesis of propargylamines in good to excellent yields under microwave-heated conditions. The propargylamine yield was 87% even when the reaction scale was increased to 150 mmol.Figure optionsDownload as PowerPoint slide