کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5910384 | 1570186 | 2013 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Non-polio enteroviruses and their association with acute diarrhea in children in India
ترجمه فارسی عنوان
انتروویروس غیر فلج اطفال و ارتباط آن با اسهال حاد در کودکان در هند
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کلمات کلیدی
RT-PCROPVsCoxsackievirus ANon-polio enteroviruscoxsackievirus BCoxsackievirusDECPAGEDiarrheagenic E. coliHFMDDiarrhea - اسهالpolyacrylamide gel electrophoresis - الکتروفورز ژل پلی آکریل آمیدEnterovirus - انتروویروسEchovirus - اکوویروسAFP - تست AFP یا آلفا فیتو پروتئینHand-foot-and-mouth disease - دست و پا و دهانRhabdomyosarcoma - رابدومیوسارکوماRotavirus - روتاویروس Acute flaccid paralysis - فلج ناگهانی حادreverse transcription-polymerase chain reaction - واکنش زنجیره ای رونویسی-پلیمراز معکوسAcute gastroenteritis - گاستروانتریت حاد
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
بوم شناسی، تکامل، رفتار و سامانه شناسی
چکیده انگلیسی
A causative agent in approximately 40% of diarrheal cases still remains unidentified. Though many enteroviruses (EVs) are transmitted through fecal-oral route and replicate in the intestinal cells, their association with acute diarrhea has not so far been recognized due to lack of detailed epidemiological investigations. This long-term, detailed molecular epidemiological study aims to conclusively determine the association of non-polio enteroviruses (NPEVs) with acute diarrhea in comaparison with rotavirus (RV) in children. Diarrheal stool specimens from 2161 children aged 0-2Â years and 169 children between 2 and 9Â years, and 1800 normal stool samples from age-matched healthy children between 0 and 9Â years were examined during 2008-2012 for enterovirus (oral polio vaccine strains (OPVs) and NPEVs). Enterovirus serotypes were identified by complete VP1 gene sequence analysis. Enterovirus and rotavirus were detected in 19.01% (380/2330) and 13.82% (322/2330) diarrheal stools. During the study period, annual prevalence of EV- and RV-associated diarrhea ranged between 8% and 22%, but with contrasting seasonal prevalence with RV predominating during winter months and NPEV prevailing in other seasons. NPEVs are associated with epidemics-like outbreaks during which they are detected in up to 50% of diarrheic children, and in non-epidemic seasons in 0-10% of the patients. After subtraction of OPV-positive diarrheal cases (1.81%), while NPEVs are associated with about 17% of acute diarrhea, about 6% of healthy children showed asymptomatic NPEV excretion. Of 37 NPEV serotypes detected in diarrheal children, seven echovirus types 1, 7, 11, 13, 14, 30 and 33 are frequently observed, with E11 being more prevalent followed by E30. In conclusion, NPEVs are significantly associated with acute diarrhea, and NPEVs and rotavirus exhibit contrasting seasonal predominance. This study signifies the need for a new direction of research on enteroviruses involving systematic analysis of their contribution to diarrheal burden.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Infection, Genetics and Evolution - Volume 17, July 2013, Pages 153-161
Journal: Infection, Genetics and Evolution - Volume 17, July 2013, Pages 153-161
نویسندگان
Durga C. Rao, M. Ananda Babu, A. Raghavendra, D. Dhananjaya, Sudheendra Kumar, P.P. Maiya,