Computational identification of interplay between phosphorylation and O-β-glycosylation of human occludin as potential mechanism to impair hepatitis C virus entry

► In silico analysis of posttranslational modifications of occludin have been reported. ► Several novel phosphorylation and O-glycosylation sites have been identified. ► Activity of ERK and GSK-3 kinases have been proposed in occludin. ► Phosphorylation and O-glycosylation interplay as mechanism to impair HCV entry is reported.