کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5911547 1161367 2011 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Towards the molecular epidemiology of Mycobacterium leprae: Strategies, successes, and shortcomings
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک بوم شناسی، تکامل، رفتار و سامانه شناسی
پیش نمایش صفحه اول مقاله
Towards the molecular epidemiology of Mycobacterium leprae: Strategies, successes, and shortcomings
چکیده انگلیسی

Mycobacterium leprae, the causative agent of leprosy, is an unusual organism that presents unique challenges to those studying the disease through molecular epidemiology. As a consequence, many basic aspects of disease transmission and biology remain unilluminated. In this review, we explore the general principles of molecular epidemiology, and the special difficulties surrounding the application of molecular epidemiology to M. leprae. We briefly discuss the computational tools commonly employed in molecular epidemiology studies. The past decade of developments in molecular strain typing approaches through VNTRs and SNP loci, and their merits and limitations, are discussed. We summarize what has been learned about the transmission and historical origins of leprosy through molecular epidemiology and Bacterial Population Genetics, to date. Lastly, we critically evaluate the strengths and shortcomings of leprosy research, and present recommendations for future work that will hopefully shed light on some of the disease's most fundamental mysteries.

► We explore the special difficulties of the molecular epidemiology of Mycobacterium leprae. ► We discuss the computational tools typically used in molecular epidemiology studies. ► We discuss the genetic markers typically used in molecular epidemiology studies. ► We summarize the M. leprae transmission and Bacterial Population Genetics to date.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Infection, Genetics and Evolution - Volume 11, Issue 7, October 2011, Pages 1505-1513
نویسندگان
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