G6PD A−variant influences the antibody responses to Plasmodium falciparum MSP2

► We assessed the impact of sickle-cell, α(+)-thalassemia and G6PD variants on antibody kinetics. ► IgG to MSP2/3D7 and MSP2/FC27 proteins were measured at the beginning and at the end of malaria transmission season. ► G6PD A− carriers had a lower increase of IgG3 levels to MSP2 during the transmission season than the noncarriers. ► The reduction of exposure to malarial antigens related to G6PD A− could lead to weaker stimulation of specific antibody responses.