Skeletal deformations in medaka (Oryzias latipes) visualized by synchrotron radiation micro-computer tomography (SRμCT)

Synchrotron radiation micro-computer tomography (SRμCT) offers the possibility to investigate biomineralized structures in high detail. Two animals of adult medaka fish (Oryzias latipes) were analyzed by SRμCT with a resolution of 6.55 μm: the wild-type animal was normally developed whereas the second animal showed an idiopathic deformation of the cranial and axial skeleton. These deformations could be followed on the macro- and on the microscale (i.e., on the level of the individual ribs and fin bones). Our study clearly demonstrates that SRμCT is an excellent technique to study alterations in the skeletal structure of fish in detail.