Molecular cloning and analysis of Ancylostoma ceylanicum glutamate-cysteine ligase

- Ace-GCL is composed of the catalytic (Ace-GCLC) and the modifier subunit (Ace-GCLM).
- The highest level of Ace-GCLC and Ace-GCLM expression occurs in adult worms.
- Vaccination with Ace-GCL results in no worm burden reduction.