کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5915989 1163353 2008 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The PCome of Caenorhabditis elegans as a prototypic model system for parasitic nematodes: Identification of phosphorylcholine-substituted proteins
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی مولکولی
پیش نمایش صفحه اول مقاله
The PCome of Caenorhabditis elegans as a prototypic model system for parasitic nematodes: Identification of phosphorylcholine-substituted proteins
چکیده انگلیسی
In this study we have analyzed the PCome of C. elegans to identify the PCho-modified proteins. Furthermore, we investigated the dynamics of this modification by analyzing the different developmental stages of this nematode. Our results demonstrate highly dynamic changes of this modification during development. Furthermore, we could show that this substitution can occur on proteins with large functional diversity and subcellular localization. We could further demonstrate that the PCho-modification greatly depends on proper N-glycosylation. However, there is clear indication that there might be a high structural diversity of the PCho-epitopes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular and Biochemical Parasitology - Volume 161, Issue 2, October 2008, Pages 101-111
نویسندگان
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