کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5916831 1163757 2015 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Allergic responses and aryl hydrocarbon receptor novel pathway of mast cell activation
ترجمه فارسی عنوان
پاسخ های آلرژیک و راه های جدیدی از گیرنده های مولکول گیرنده های آرویل هیدروکربن
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی مولکولی
چکیده انگلیسی
The activation of the transcription factor aryl hydrocarbon receptor (AhR) is modulated by a wide variety of xenobiotics and ligands deriving from products of metabolism. The study of the contribution of AhR to allergic diseases has gained much interest in recent years. Here we discuss the role that environmental factors and metabolic products, particularly acting on AhR-expressing mast cells (MCs), could have in the development of local allergic/atopic response. Thus, this review will cover: a brief overview of the AhR mechanism of action in the immune system; a description of different AhR ligands and their effects to IgE-mediated MC activation in the allergic response, with particular attention to the role of IL-17; a discussion about the potential involvement of AhR in immune tolerance; and a conclusion on human diseases in which direct AhR activation of MC might have a major impact.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular Immunology - Volume 63, Issue 1, January 2015, Pages 69-73
نویسندگان
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