کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5916920 | 1163765 | 2013 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
RAGE and TLRs: Relatives, friends or neighbours?
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کلمات کلیدی
DAMPPAMPTLRHMGB1PRRLPSReceptor for advanced glycation end products (RAGE)RAGEdamage-associated molecular pattern - الگوی مولکولی مرتبط با آسیبpathogen-associated molecular pattern - الگوی مولکولی وابسته به پاتوژنToll-like receptor - تیالآرLipopolysaccharide (LPS) - لیپوپلی ساکارید (LPS)Lipopolysaccharides - لیپوپلی ساکارید هاS100 proteins - پروتئین S100high mobility group box-1 - گروه تحریر بالا box-1Receptor for advanced glycation end products - گیرنده برای محصولات پیشرفته glycation پایانToll-like receptors (TLRs) - گیرنده های Toll-like (TLRs)PRR, Pattern recognition receptor - گیرنده های شناسایی الگو
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شناسی مولکولی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The innate immune system forms the first line of protection against infectious and non-infectious tissue injury. Cells of the innate immune system detect pathogen-associated molecular patterns or endogenous molecules released as a result of tissue injury or inflammation through various innate immune receptors, collectively termed pattern-recognition receptors. Members of the Toll-like receptor (TLR) family of pattern-recognition receptors have well established roles in the host immune response to infection, while the receptor for advanced glycation end products (RAGE) is a pattern-recognition receptor predominantly involved in the recognition of endogenous molecules released in the context of infection, physiological stress or chronic inflammation. RAGE and TLRs share common ligands and signaling pathways, and accumulating evidence points towards their co-operative interaction in the host immune response. At present however, little is known about the mechanisms that result in TLR versus RAGE signalling or RAGE-TLR cross-talk in response to their shared ligands. Here we review what is known in relation to the physicochemical basis of ligand interactions between TLRs and RAGE, focusing on three shared ligands of these receptors: HMGB1, S100A8/A9 and LPS. Our aim is to discuss what is known about differential ligand interactions with RAGE and TLRs and to highlight important areas for further investigation so that we may better understand the role of these receptors and their relationship in host defense.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular Immunology - Volume 56, Issue 4, 31 December 2013, Pages 739-744
Journal: Molecular Immunology - Volume 56, Issue 4, 31 December 2013, Pages 739-744
نویسندگان
Zaridatul Aini Ibrahim, Carol L. Armour, Simon Phipps, Maria B. Sukkar,