کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5916997 | 1163767 | 2013 | 10 صفحه PDF | دانلود رایگان |
Endocrine disrupting chemicals (EDCs) have become of concern for a variety f health issues. Due to their effects on the endocrine system they have been thoroughly examined with regards to sexual dysfunction, malformation, and cancers of reproductive origin. Bisphenol-A (BPA) is a widely studied EDC and has been characterized regarding its estrogenic effects on a variety of cell types. BPA also alters immune responses. In this review, we examine some of the documented effects of EDCs, with a focus on BPA that pertain to modulation of the immune system and various immune cell populations. We highlight the multiple actions of BPA on altering T cell subsets, B cell functions, and dendritic cell and macrophage biology. Finally, we consider that these immunological activities of BPA may be mediated through estrogen receptor signaling, arylhydrocarbon receptor, and the peroxisome proliferator-activated receptor family of nuclear receptors.
⺠Exposure to endocrine disrupting chemicals, specifically Bisphenol-A, is common. ⺠Bisphenol-A produces several effects on various immune cell types. ⺠Bisphenol-A affects immunity through a variety of intracellular receptors.
Journal: Molecular Immunology - Volume 53, Issue 4, April 2013, Pages 421-430