Zymosan activates protein kinase A via adenylyl cyclase VII to modulate innate immune responses during inflammation

► Zymosan particles increase cAMP and activation of PKA in macrophage cells. ► These responses depend on AC7 and heterotrimeric G proteins, primarily G12/13. ► Macrophage cells deficient of AC7 produce more TNFα in response to zymosan. ► Mice without myeloid AC7 show prolonged inflammation in zymosan induced peritonitis.