ESAT-6 induced COX-2 expression involves coordinated interplay between PI3K and MAPK signaling

► We examined the mechanistic details of ESAT-6 triggered COX-2 expression. ► ESAT-6 triggers COX-2 expression in TLR2 dependent manner. ► ESAT-6 induced COX-2 expression involves cross-talk of PI3K and MAPK signaling axis. ► COX-2 expression is dependent on coordinated activation of NF-κB and AP-1.