Factor H gene variants in Japanese: Its relation to atypical hemolytic uremic syndrome

► We analyze FH1 in Japanese aHUS. ► Japanese aHUS have FH1 mutations in its exon 23. ► Interestingly, healthy Japanese have the well-known disease risk polymorphisms for aHUS. Although FH1 mutations relates to the development of Japanese aHUS, other factor may be required for factor H polymorphism to be a risk factor of Japanese aHUS.