Effect of rhTACI-Ig fusion protein on antigen-specific T cell responses from keyhole limpet haemocyanin challenged mice

► KLH immunization leaded to a significant positive relationship between BAFF level in serum and the extent of spleen histopathology. ► KLH-challenged C57/BL6 mice indicated a bias of Th2 cytokine dominance. ► The inhibitory effects of rhTACI-Ig on antigen-specific T cells might be associated with its ability to neutralize both the exogenous and endogenetic BAFF and APRIL.