Structural basis of cross-allele presentation by HLA-A*0301 and HLA-A*1101 revealed by two HIV-derived peptide complexes

► Overall structure and the peptide presentation of HLA-A*0301 are comparable to HLA-A*1101. ► The overall similarity is responsible for the cross-recognition of HLA-A* 0301 and HLA-A*1101. ► The key polymorphic amono acids are responsible for their antigen-presenting properties and TCR-recognition surfaces.