کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5919580 | 1570820 | 2014 | 6 صفحه PDF | دانلود رایگان |
- A new three-matrix model is developed for Pancrustacea mitochondrial genomes.
- Alignment sites are clustered according to physiochemical values.
- Multiple substitution matrices are estimated, one from each site group.
- The new multiple matrix model MtPAN3 outperforms available single matrix models.
- A R/BioPerl script is provided to perform matrix transformation and clustering.
Phylogenetic analyses of Pancrustacea have generally relied on empirical models of amino acid substitution estimated from large reference datasets and applied to the entire alignment. More recently, following the observation that different sites, or groups of sites, may evolve under different evolutionary constraints, methods have been developed to deal with site or site-class specific models.A set of three matrices has been here developed based on an alignment of complete mitochondrial pancrustacean genomes partitioned using an unsupervised clustering procedure acting over per-site physiochemical properties. The performance of the proposed matrix set - named MtPAN3 - was compared to relevant single matrix models (MtZOA, MtART, MtPAN) under ML and BI. While the application of the new model does not solve some of the topological problems frequently encountered with pancrustacean mitogenomic phylogenetic analyses, MtPAN3 largely outperforms its competitors based on AIC and Bayes factors, indicating a significantly improved fit to the empirical data. The applicability of the new model, as well as of multiple matrix models in general, is discussed and an R/BioPerl script that implements the procedure is provided.
Journal: Molecular Phylogenetics and Evolution - Volume 75, June 2014, Pages 239-244