کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5924414 | 1571189 | 2014 | 30 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A terrified-sound stress induced proteomic changes in adult male rat hippocampus
ترجمه فارسی عنوان
استرس وحشت زده شده باعث تغییرات پروتئومیک در هیپوکامپ موش بالایی مرد می شود
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کلمات کلیدی
استرس وحشت زده یادگیری فضایی و حافظه، هیپوکامپ، بیان پروتئین،
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
فیزیولوژی
چکیده انگلیسی
In this study, we investigated the biochemical mechanisms in the adult rat hippocampus underlying the relationship between a terrified-sound induced psychological stress and spatial learning. Adult male rats were exposed to a terrified-sound stress, and the Morris water maze (MWM) has been used to evaluate changes in spatial learning and memory. The protein expression profile of the hippocampus was examined using two-dimensional gel electrophoresis (2DE), matrix-assisted laser desorption/ionization time-of-flight mass spectrometry, and bioinformatics analysis. The data from the MWM tests suggested that a terrified-sound stress improved spatial learning. The proteomic analysis revealed that the expression of 52 proteins was down-regulated, while that of 35 proteins were up-regulated, in the hippocampus of the stressed rats. We identified and validated six of the most significant differentially expressed proteins that demonstrated the greatest stress-induced changes. Our study provides the first evidence that a terrified-sound stress improves spatial learning in rats, and that the enhanced spatial learning coincides with changes in protein expression in rat hippocampus.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Physiology & Behavior - Volume 128, 10 April 2014, Pages 32-38
Journal: Physiology & Behavior - Volume 128, 10 April 2014, Pages 32-38
نویسندگان
Juan Yang, Lili Hu, Qiuhua Wu, Liying Liu, Lingyu Zhao, Xiaoge Zhao, Tusheng Song, Chen Huang,