کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5924742 | 1571199 | 2013 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Roles of levo-tetrahydropalmatine in modulating methamphetamine reward behavior
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کلمات کلیدی
CPPEXTi.pL-THPl-TetrahydropalmatineExtinction - انقراضAcquisition - اکتساب، حاکمیتReinstatement - بازگرداندنconditioned place preference - ترجیح محل موظف استintraperitoneal - داخل صفاقیDopamine - دوپامینRein - رینLevo-tetrahydropalmatine - لوو تتراهیدروپالماتینMETH - متهMethamphetamine - متیل آمفتامین
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
فیزیولوژی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
Levo-tetrahydropalmatine (l-THP), as an alkaloid purified from the traditional Chinese herbal medicine Corydalis and Stephania, has been widely used to produce many traditional Chinese herbal preparations. The effect of l-THP on methamphetamine-induced reward learning still remains unclear although it has been proved to be effective on treating allodynia and drug addiction. This experiment has been designed to examine the effect of l-THP on the acquisition, expression, extinction, and reinstatement of methamphetamine-induced conditioned place preference (CPP) in mice. The results show that methamphetamine (METH) could induce CPP in mice at doses of 0.5Â mg/kg, 1.0Â mg/kg and 2.0Â mg/kg respectively, but l-THP alone could not do so. Meanwhile, l-THP could not induce conditioned place aversion at doses of 1.25Â mg/kg to 20.0Â mg/kg in mice, but it could attenuate the acquisition and expression of METH-induced CPP and facilitate the extinction of METH-induced CPP in mice. Besides, l-THP could inhibit the reinstatement of METH-induced CPP at the dose of 10.0Â mg/kg whether it was given in the extinction training phase or 30Â min before the reinstatement. These results suggest that l-THP can globally suppress the rewarding properties of METH on all phases of the CPP task and it may have potential effects on the treatment of METH abuse.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Physiology & Behavior - Volume 118, 13 June 2013, Pages 195-200
Journal: Physiology & Behavior - Volume 118, 13 June 2013, Pages 195-200
نویسندگان
Hong-Liang Su, Jie Zhu, Yan-Jiong Chen, Na Zhao, Wei Han, Yong-Hui Dang, Ming Xu, Teng Chen,