TRPM2 channel protective properties of N-acetylcysteine on cytosolic glutathione depletion dependent oxidative stress and Ca2+ influx in rat dorsal root ganglion

► TRPM2 currents and Ca2+ levels in glutathione depleted dorsal root ganglion (DRG) neuron were increased. ► N-acetylcysteine (NAC) supplementation modulated the values. ► The current study is the first to compare treatment with NAC to TRPM2 currents and Ca2+ influx in the DRG neurons.