کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5925406 | 1166347 | 2012 | 10 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Melatonin modulates wireless (2.45 GHz)-induced oxidative injury through TRPM2 and voltage gated Ca2+ channels in brain and dorsal root ganglion in rat Melatonin modulates wireless (2.45 GHz)-induced oxidative injury through TRPM2 and voltage gated Ca2+ channels in brain and dorsal root ganglion in rat](/preview/png/5925406.png)
We aimed to investigate the protective effects of melatonin and 2.45Â GHz electromagnetic radiation (EMR) on brain and dorsal root ganglion (DRG) neuron antioxidant redox system, Ca2+ influx, cell viability and electroencephalography (EEG) records in the rat. Thirty two rats were equally divided into four different groups namely group A1: Cage control, group A2: Sham control, group B: 2.45Â GHz EMR, group C: 2.45Â GHz EMRÂ +Â melatonin. Groups B and C were exposed to 2.45Â GHz EMR during 60Â min/day for 30Â days. End of the experiments, EEG records and the brain cortex and DRG samples were taken. Lipid peroxidation (LP), cell viability and cytosolic Ca2+ values in DRG neurons were higher in group B than in groups A1 and A2 although their concentrations were increased by melatonin, 2-aminoethyldiphenyl borinate (2-APB), diltiazem and verapamil supplementation. Spike numbers of EEG records in group C were lower than in group B. Brain cortex vitamin E concentration was higher in group C than in group B. In conclusion, Melatonin supplementation in DRG neurons and brain seems to have protective effects on the 2.45Â GHz-induced increase Ca2+ influx, EEG records and cell viability of the hormone through TRPM2 and voltage gated Ca2+ channels.
⺠Brain electroencephalography (EEG) spike numbers, dorsal root ganglion (DRG) neuron lipid peroxidation, cell viability and Ca2+ influx values in electromagnetic radiation (EMR) group were increased compared with controls. ⺠However, melatonin supplementation modulated the values. ⺠The current study is the first to compare treatment with melatonin to EEG records, oxidative stress and Ca2+ homeostasis in brain and DRG neuron of EMR exposed rat.
Journal: Physiology & Behavior - Volume 105, Issue 3, 1 February 2012, Pages 683-692