کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5925602 1166353 2012 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Pontine and thalamic influences on fluid rewards: I. Operant responding for sucrose and corn oil
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی فیزیولوژی
پیش نمایش صفحه اول مقاله
Pontine and thalamic influences on fluid rewards: I. Operant responding for sucrose and corn oil
چکیده انگلیسی

The reward strength of orosensory sucrose and corn oil was measured using fixed and progressive ratio operant schedules. Because the orosensory effects of the stimuli were of interest, Experiment 1 compared operant responses for sucrose in sham and real feeding rats. The results demonstrated that rats would work for sucrose solutions without the accompanying postingestive effects. Furthermore, the break points for high concentrations of sucrose (1.0 M or 2.0 M) were significantly higher in sham feeding rats than in real feeding controls. Experiment 2 investigated the role of the parabrachial nucleus (PBN) and of the thalamic orosensory area (TOA) in sucrose and corn oil reward. During free access, rats with PBN lesions (PBNx) licked significantly less sucrose solution than their controls, but both groups ingested a similar volume of corn oil emulsion. When an operant was imposed, these same PBNx rats failed to respond for sucrose and continued only modestly for corn oil. In contrast, the TOA lesioned rats (TOAx) showed no impairment in responding for sucrose or corn oil during either the free access or operant sessions. Furthermore, rats with TOA lesions demonstrated significantly higher break points for sucrose than did their controls. Together, the data imply that the PBN but not the TOA is critical for the perception of, or responding to the reward value of sucrose and corn oil.

Research highlights► Orosensory stimulation with sucrose or corn oil alone can support operant responding. ► Rats with PBN lesions lick oil but not sucrose at a normal rate during free access. ► PBNx rats failed to work for either sucrose or corn oil reward in operant tasks. ► TOAx rats responded either equally or more for both rewards than the controls.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Physiology & Behavior - Volume 105, Issue 2, 18 January 2012, Pages 576-588
نویسندگان
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