کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5931835 1573136 2015 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Curcumin Inhibits Apoptosis and Brain Edema Induced by Hypoxia-Hypercapnia Brain Damage in Rat Models
ترجمه فارسی عنوان
کورکومین مهار کننده آپوپتوز و ادم مغزی ناشی از آسیب مغزی هیپوکسی-هیپرکاپنیا در مدل موش
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی
Curcumin, extracted from South Asian spice turmeric, has been determined to have the promising ability in antioxidation and antiinflammation. However, the effect of curcumin on treating brain damage has been not reported. in this article, the aim was to evaluate the effect of curcumin on cell apoptosis in rats exposed to hypoxia-hypercapnia and explore the therapeutic potential of curcumin in hypoxia-hypercapnia brain damage (HHBD). sprague Dawley rats were randomly assigned into 3 groups: control group, hypoxia-hypercapnia group and curcumin group. The Fas/FasL expressions in HHBD rats treated by curcumin were measured by immunohistochemical staining and western blotting. The pathological changes of brain cells were observed by transmission electron microscope. Rats with HHBD showed significant increase of Fas/FasL expression and ultrastructural changes in brain tissue cells. Curcumin intervention effectively reversed the Fas/FasL-mediated apoptosis and HHBD-induced brain edema. Curcumin may be a potential therapeutic alternative for HHBD.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The American Journal of the Medical Sciences - Volume 349, Issue 6, June 2015, Pages 521-525
نویسندگان
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