کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5962019 1176166 2014 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Dofetilide induced torsade de pointes: Mechanism, risk factors and management strategies
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Dofetilide induced torsade de pointes: Mechanism, risk factors and management strategies
چکیده انگلیسی

Dofetilide is an effective antiarrhythmic agent for conversion of atrial fibrillation and atrial flutter as well as maintenance of sinus rhythm in appropriately selected patients. However, as with other antiarrhythmic agents, proarrhythmia is a known adverse effect. The risk of dofetilide induced torsade de pointes (Tdp) is low when used with strict dosing criteria guided by renal function, QT interval and concomitant drug therapy. Benefit from dofetilide use must be individualized and weighed against the side effects and the role of other available treatment options. In this review, we discuss the underlying mechanism, risk factors and precautionary measures to avoid dofetilide induced QT prolongation and ventricular tachycardia/Tdp. We suggest a scheme for the management of QT prolongation, ventricular arrhythmia and Tdp as well.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Indian Heart Journal - Volume 66, Issue 6, November–December 2014, Pages 640-648
نویسندگان
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