One-pot synthesis of 1-amidoalkyl-2-naphthols catalyzed by melamine-Br3 under solvent-free conditions

A facile and efficient method has been developed for the synthesis of 1-amidoalkyl-2-naphthols via the one-pot multi-component condensation of 2-naphthol with aromatic aldehydes and acetamide or thioacetamide in the presence of melamine-Br3 under solvent-free conditions. There are several advantages to this reaction, including high yields, short reaction time, and high catalytic efficiency.

Graphical AbstractMelamine-Br3 has been shown to be an efficient and non-acidic catalyst for the condensation of 2-naphthol with aldehydes and acetamide or thioacetamide.Figure optionsDownload as PowerPoint slide