کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5963363 1576128 2016 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Atrial tissue expression of receptor for advanced glycation end-products (RAGE) and atrial fibrosis in patients with mitral valve disease
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Atrial tissue expression of receptor for advanced glycation end-products (RAGE) and atrial fibrosis in patients with mitral valve disease
چکیده انگلیسی

BackgroundIt has been reported that receptor for advanced glycation end-products (RAGE) plays a significant role in cardiac fibrosis. Nonetheless, the precise relationship between the RAGE and atrial fibrosis has never been studied in humans. The aim of this study was to determine whether degree of atrial fibrosis was associated with atrial tissue expression of RAGE in patients with mitral valve disease (MVD).MethodsWe collected human left atrial (LA) appendage tissue from 25 patients who underwent mitral valve surgery. We quantified the expression of RAGE and other protein markers by Western blotting and compared these levels with histological evaluations.ResultsRAGE expression in the LA appendage tissue was significantly correlated with atrial fibrosis (r = 0.681, p = 0.001). RAGE expression (regression coefficient [B] 9.49, 95% confidence interval [CI] 4.76-14.2, p < 0.001) and LA diameter (B 0.43, 95% CI 0.13-0.74, p = 0.008) were independently associated with degree of atrial fibrosis in multiple linear regression analysis. RAGE expression was significantly correlated with protein expression of von Willebrand factor (r = 0.659, p < 0.001), vascular endothelial cadherin (r = 0.757, p < 0.001), ICAM-1 (r = 0.568, p = 0.003), and PECAM-1 (r = 0.423, p = 0.035) in the LA appendage tissue. In addition, patients with severe mitral stenosis (MS) had higher atrial RAGE expression than those with no, mild, or moderate MS (p = 0.013). Patients with MVD and atrial fibrillation (AF) had more severe atrial fibrosis (p = 0.024) and higher RAGE expression (p = 0.047) than those who remained in sinus rhythm.ConclusionsAtrial tissue expression of RAGE was significantly associated with atrial fibrosis, severe MS, and AF rhythm in patients with MVD.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Cardiology - Volume 220, 1 October 2016, Pages 1-6
نویسندگان
, , , , , , , , ,