Quantitative comparison of 2D and 3D late gadolinium enhancement MR imaging in patients with Fabry disease and hypertrophic cardiomyopathy

BackgroundThis study aims to determine whether the quantification of myocardial fibrosis in patients with Fabry disease (FD) and hypertrophic cardiomyopathy (HCM) using a late gadolinium enhancement (LGE) singlebreath-hold three-dimensional (3D) inversion recovery magnetic resonance (MR) imaging sequence is comparable with a clinically established two-dimensional (2D) multi-breath-hold sequence.MethodsIn this retrospective, IRB-approved study, 40 consecutive patients (18 male; mean age 50 ± 17 years) with Fabry disease (n = 18) and HCM (n = 22) underwent MR imaging at 1.5 T. Spatial resolution was the same for 3D and 2D images (field-of-view, 350 × 350 mm2; in-plane-resolution, 1.2 × 1.2 mm2; section-thickness, 8 mm). Datasets were analyzed for subjective image quality; myocardial and fibrotic mass, and total fibrotic tissue percentage were quantified.ResultsThere was no significant difference in subjective image quality between 3D and 2D acquisitions (P = 0.1 and P = 0.3) for either disease. In patients with Fabry disease there were no significant differences between 3D and 2D acquisitions for myocardial mass (P = 0.55), fibrous tissue mass (P = 0.89), and total fibrous percentage (P = 0.67), with good agreement between acquisitions according to Bland-Altman analyses. In patients with HCM there were also no significant differences between acquisitions for myocardial mass (P = 0.48), fibrous tissue mass (P = 0.56), and total fibrous percentage (P = 0.67), with good agreement according to Bland-Altman analyses. Acquisition time was significantly shorter for 3D (25 ± 5 s) as compared to the 2D sequence (349 ± 62 s, P < 0.001).ConclusionsIn patients with Fabry disease and HCM, 3D LGE imaging provides equivalent diagnostic information in regard to quantification of myocardial fibrosis as compared with a standard 2D sequence, but at superior acquisition speed.