کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5964644 1576135 2016 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The effect of statins on mortality in heart failure with preserved ejection fraction: a meta-analysis of propensity score analyses
ترجمه فارسی عنوان
اثر استاتین ها در مرگ و میر ناشی از نارسایی قلبی با کسر خروج حفظ شده: یک متاآنالیز تجزیه و تحلیل نمره گرایش
کلمات کلیدی
نارسایی قلبی با کسر تخلیه محافظت شده، استاتین ها، متاآنالیز، تجزیه و تحلیل نمره گرایش،
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی

BackgroundNearly half of patients with heart failure (HF) have preserved ejection fraction (EF) and the mortality and morbidity of patients with HF with preserved EF (HFpEF) are high. However, no pharmacological therapy has been shown to improve survival in HFpEF patients. Previous retrospective and prospective observational studies have examined the prognostic impact of hydroxymethylglutaryl-coenzyme A reductase inhibitors (statins) in patients with HFpEF. However, the results are inconsistent due to limited power with small sample sizes and/or lack of adjustment for known prognostic factors and differences in baseline characteristics between patients treated with and without statins.MethodsWe aimed to conduct a meta-analysis of prospective observational studies examining the effect of statin therapy on mortality in HFpEF patients with the use of propensity score analysis.ResultsA total of 4 studies with 5,536 patients (2,768 patients [50%] on statins; mean age, 65-77 years; male, 43-66%; coronary artery disease, 42-64%; hypertension, 61-82%; diabetes, 20-29%; follow-up duration, 12-36 months) were included in this meta-analysis. The pooled analysis showed that statin therapy was associated with reduced mortality (odds ratio [95% CI] = 0.690 [0.493-0.965], P = 0.030).ConclusionOur meta-analysis suggests the potential mortality benefit of statins in HFpEF. Further prospective observational studies and randomized controlled trials should be planned to confirm our observed potential survival benefit of statins in HFpEF.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Cardiology - Volume 214, 1 July 2016, Pages 301-306
نویسندگان
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