کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5966036 | 1576156 | 2015 | 6 صفحه PDF | دانلود رایگان |
- CHD and Heart Disease of Uncertain Etiology (HDUE) 50-year prediction.
- Four basic risk factors in a population study by Cox proportional hazards models
- Serum cholesterol was a strong predictor of CHD while it was irrelevant for HDUE.
- Age was a stronger predictor for HDUE while SBP and cigarettes predicted similarly.
- CHD and HDUE are probably manifestations of different etiologies.
ObjectivesThe relationships of four basic risk factors with 50-year incidence of coronary heart disease (CHD) and Heart Disease of Uncertain Etiology (HDUE) were investigated in a population study.Material and methodsThere were 1712 men aged 40-59Â years in 1960 and 1677, heart disease free, were followed-up for 50Â years. Incidence of first event for CHD (sudden death, fatal and non-fatal myocardial infarction, other fatal and non-fatal coronary syndromes) and HDUE (heart failure, chronic arrhythmia, blocks, “chronic CHD”, hypertensive heart disease) was estimated and the relationships of four basic risk factors analyzed.ResultsIn 50Â years incidences of CHD and HDUE were respectively 26.9 and 20.6%. Cox proportional hazards models showed serum cholesterol as a strong CHD predictor (hazard ratio, HR, for 1Â mmol/l difference 1.22 and confidence intervals, CI, 1.11 to 1.33), irrelevant for HDUE (HR 1.02 and CI 0.87 to 1.18). Age at entry was a stronger predictor for HDUE (HR for 5Â year difference 1.65 and CI 1.46 to 1.86) than for CHD (HR 1.26 and CI 1.14 to 1.39). Systolic blood pressure and cigarette smoking had similar predictive power. The diagnosis of angina pectoris (AP) recorded at any time during the study was strongly associated with CHD but not with HDUE. A HDUE subgroup with AP had similar life-expectancy to CHD, suggesting the need to re-classify them as CHD.ConclusionsDue to important differences in predictors (risk factors) and expectancy of life CHD and HDUE are probably manifestations of different etiologies.
Journal: International Journal of Cardiology - Volume 196, 1 October 2015, Pages 55-60