کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5972716 1576195 2014 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Aortic biomechanics by magnetic resonance: Early markers of aortic disease in Marfan syndrome regardless of aortic dilatation?
ترجمه فارسی عنوان
بیومکانیک آئورت توسط رزونانس مغناطیسی: مارکرهای اولیه بیماری آئورت در سندرم مارفان بدون در نظر گرفتن انقباض آئورت؟
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی

BackgroundPrevious studies demonstrated the usefulness of MRI in the evaluation of aortic biomechanics in Marfan patients with aortic dilatation. However, these parameters have not been well studied in earlier stages of aortic disease. The present work aimed to study aortic biomechanics: aortic distensibility (AD) and pulse wave velocity (PWV), by MRI in Marfan patients without advanced aortic disease.MethodsEighty consecutive Marfan patients were compared with 36 age- and sex-matched controls. MRI images at the level of ascending, descending and abdominal aorta were used to determine AD and PWV.ResultsMarfan patients (27 men; age: 32.0 ± 10.5 years; mean aortic root diameter: 37.2 ± 4.6 mm) had lower AD at all levels (ascending 2.6 ± 2.1 vs. 6.2 ± 3.7 mm Hg− 1 · 10− 3, p < 0.001; descending 3.1 ± 2.0 vs. 8.3 ± 4.2, p < 0.001; and abdominal 4.5 ± 2.2 vs. 14.0 ± 5.2, p < 0.001), higher aortic arch PWV (8.1 ± 6.5 vs. 4.3 ± 1.8 m/s, p < 0.01) and ascending-to-abdominal PWV (6.1 ± 3.0 vs. 4.7 ± 1.5 m/s, p < 0.01) compared with controls. Thirty-five Marfan patients had a non-dilated aortic root (mean aortic root diameter: 34.5 ± 3.8 mm). In multivariable analyses, after adjustment for age, pulse pressure and aortic dimensions, AD remained lower and PWV higher in Marfan patients; even Marfan patients with non-dilated aortic root showed impaired aortic biomechanics compared with controls. Z-score for ascending AD < − 3.5 distinguished Marfan patients from controls with 82.5% sensitivity and 86.1% specificity.ConclusionsAortic biomechanics by MRI were abnormal in the entire aorta in Marfan patients. Moreover, Marfan patients without dilated aortic root showed clear impairment of aortic biomechanics, which suggests that they may be used as early markers of aortic involvement in these patients.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Cardiology - Volume 171, Issue 1, 15 January 2014, Pages 56-61
نویسندگان
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