کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5973343 1576207 2013 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Distinctive sodium and calcium regulation associated with sex differences in atrial electrophysiology of rabbits
ترجمه فارسی عنوان
تنظیم سدیم و کلسیم متمایز با اختلالات جنسی در الکتروفیزیولوژی دهلیزی خرگوش
کلمات کلیدی
فیبریلاسیون دهلیزی، ارتباط جنسی، سدیم، کلسیم، دیواره خلفی دهلیزی چپ،
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی

BackgroundSex and sodium/calcium regulation play critical roles in cardiac electrophysiology and atrial arrhythmogenesis. We investigated whether sodium and calcium contributed to sex differences in atrial electrophysiology.MethodsWhole-cell patch clamp techniques and the indo-1 fluorometric ratio technique were used to investigate the ionic current and intracellular calcium in single isolated male and female rabbit myocytes from the left atrium posterior wall (LAPW) and right atrium (RA).ResultsFemale LAPW (n = 95) and RA (n = 49) myocytes had larger cell widths (15.1 ± 0.4 vs. 13.8 ± 0.4 μm, p < 0.05; 14.9 ± 0.6 vs. 13.5 ± 0.4 μm, p < 0.05) than male LAPW (n = 142) and RA (n = 57) myocytes. Male LAPW myocytes (n = 26) had a higher incidence (57 vs. 16%, p < 0.05) of delayed afterdepolarizations (DADs) than female LAPW myocytes (n = 24) but there were similar incidences (20 vs. 20%, p > 0.05) of DADs in male and female RA myocytes. The late sodium current, calcium transients, and sarcoplasmic reticulum calcium contents were larger in male than female LAPW myocytes but were similar in male and female RA myocytes. However, the ICa-L and nickel-sensitive sodium/calcium exchanger currents were similar between two groups. Different from those in female myocytes, ouabain (10 μM) only induced repeated atrial beats (0 to 45%, p < 0.05) in male myocytes (n = 11). Moreover, ranolazine (3 μM) perfusion (4.5 ± 0.6 vs. 1 min, p < 0.05) was required to decrease the amplitude of DADs in male but not female LAPW myocytes.ConclusionsIncreased late sodium currents and calcium contents may contribute to higher arrhythmogenesis in male LAPW myocytes.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Cardiology - Volume 168, Issue 5, 12 October 2013, Pages 4658-4666
نویسندگان
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