کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5973988 1576202 2013 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Real-life effectiveness of statins in the prevention of first acute coronary syndrome in France: A prospective observational study
ترجمه فارسی عنوان
اثربخشی واقعی استاتین ها در جلوگیری از اولین سندرم حاد کرونری در فرانسه: یک مطالعه مشاهده ای آینده ای
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی

BackgroundEvidence on the real effectiveness of statins on acute coronary syndrome (ACS) incidence is scarce. We assessed the effectiveness of real-life statins on the risk of first non-fatal ACS in a low-cardiovascular-risk country.MethodsSystematic case-control study was conducted in 60 cardiology centres and 371 general practices from across France. A total of 2238 cases with first ACS within 1 month from recruitment and 2238 controls without history of ACS were included; controls were matched to ACS cases on sex, age, frequency of visits to GPs, date of recruitment and personal history of chronic diseases. Statin exposure and risk factors were documented through patient telephone interviews and validated against medical records. The index date was the date of ACS for cases. Adjusted odds ratios (OR) of first ACS and statin use were estimated by multiple conditional logistic regression models controlled for risk factors and propensity score for statin exposure.ResultsStatin use was associated with lower ACS risk, with an adjusted matched OR of 0.67; 95% confidence interval (CI): 0.56 to 0.79 for current use (within 2 months) and 0.73; 95% CI: 0.62 to 0.86 for any use within 24 months [atorvastatin: 0.83 (0.63-1.10), fluvastatin: 0.75 (0.43-1.30), pravastatin: 0.98 (0.72-1.34), rosuvastatin: 0.49 (0.35-0.68) and simvastatin: 0.62 (0.46-0.84)]. The preventive effect of statins on non-fatal ACS reached its maximum after one to four years of use.ConclusionA similar magnitude of effect for statin use was observed in real life, as compared to randomised clinical trials in France.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Cardiology - Volume 169, Issue 4, 15 November 2013, Pages 271-275
نویسندگان
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