کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5975492 | 1576214 | 2013 | 8 صفحه PDF | دانلود رایگان |
BackgroundTo determine the comparative effectiveness and costs of a CT-strategy and a stress-electrocardiography-based strategy (standard-of-care; SOC-strategy) for diagnosing coronary artery disease (CAD).MethodsA decision analysis was performed based on a well-documented prospective cohort of 471 outpatients with stable chest pain with follow-up combined with best-available evidence from the literature. Outcomes were correct classification of patients as CADâ (no obstructive CAD), CAD+ (obstructive CAD without revascularization) and indication for Revascularization (using a combination reference standard), diagnostic costs, lifetime health care costs, and quality-adjusted life years (QALY). Parameter uncertainty was analyzed using probabilistic sensitivity analysis.ResultsFor men (and women), diagnostic cost savings were â¬245 (â¬252) for the CT-strategy as compared to the SOC-strategy. The CT-strategy classified 82% (88%) of simulated men (women) in the appropriate disease category, whereas 83% (85%) were correctly classified by the SOC-strategy. The long-term cost-effectiveness analysis showed that the SOC-strategy was dominated by the CT-strategy, which was less expensive (â â¬229 in men, â â¬444 in women) and more effective (+ 0.002 QALY in men, + 0.005 in women). The CT-strategy was cost-saving (â â¬231) but also less effective compared to SOC (â 0.003 QALY) in men with a pre-test probability of â¥Â 70%. The CT-strategy was cost-effective in 100% of simulations, except for men with a pre-test probability â¥Â 70% in which case it was 59%.ConclusionsThe results suggest that a CT-based strategy is less expensive and equally effective compared to SOC in all women and in men with a pre-test probability < 70%.
Journal: International Journal of Cardiology - Volume 167, Issue 4, 20 August 2013, Pages 1268-1275