کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5976664 1576211 2013 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Prognostic value of plasma von Willebrand factor and its cleaving protease ADAMTS13 in patients with atrial fibrillation
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Prognostic value of plasma von Willebrand factor and its cleaving protease ADAMTS13 in patients with atrial fibrillation
چکیده انگلیسی

BackgroundThe von Willebrand factor (vWF) is essential for platelet adhesion and arterial thrombosis. It is degraded into less active multimers by ADAMTS13. Patients with atrial fibrillation (AF) exhibit higher plasma vWF and lower ADAMTS13 antigen levels. The vWF/ADAMTS13-ratio might help to estimate the pro-thrombotic risk of patients with AF. We therefore investigated whether a high ratio of vWF/ADAMTS13, independently of clinical risk scores, predicts major adverse cardiovascular events (MACE) in patients with AF.MethodsThis prospective longitudinal single center study included 269 patients with AF. Blood samples were analyzed for vWF and ADAMTS13-antigen concentration by means of enzyme-linked immunoassay kits.ResultsAfter adjustment for all univariable predictors for MACE (p ≤ 0.1), ADAMTS13 ≤ 49.77% (HR 1.833 (95% CI 1.089-3.086); p = 0.023) and vWF/ADAMTS13-ratio > 27.57 (HR 2.174 (95% CI 1.238-3.817); p = 0.007) remained independently associated with outcome. vWF > 1434.92 mU/ml (HR 1.539 (95% CI 0.883-2.682); p = 0.128) alone failed to independently predict MACE. In patients with low and intermediate risk for MACE according to the CHADS2-score the addition of high vWF/ADAMTS13-ratio levels (> 27.57) had significant impact on the patients' outcome.ConclusionA high ratio of vWF/ADAMTS13 independently predicts MACE in patients with AF. Therefore, vWF and its cleaving protease ADAMTS13 might play an important role in the development and perpetuation of vascular disease in AF patients. This might be a novel target for future treatment strategies or an additional help for risk stratification in AF patients.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Cardiology - Volume 168, Issue 1, 20 September 2013, Pages 317-325
نویسندگان
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