کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5976853 1576222 2013 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Clinical and electrocardiographic predictors of positive response to the intravenous sodium channel blockers in patients suspected of the Brugada syndrome
ترجمه فارسی عنوان
پیش بینی کننده های بالینی و الکتروکاردیوگرافی پاسخ مثبت به مسدود کننده های کانال سدیم وریدی در بیماران مظنون به سندرم بروگادا
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی

Background/objectivesSodium channel blockers are used to unmask the diagnostic ECG pattern of the Brugada syndrome (BrS) in case of a non-diagnostic baseline ECG. The aim of the study was to determine clinical and ECG predictors of a positive challenge test in patients suspected to the BrS.MethodsA total of 106 consecutive patients (91 men; mean age, 35 ± 12 years) suspected of the BrS underwent the intravenous sodium channel blocker challenge test with procainamide or flecainide.ResultsOf the 106 patients, positive tests were detected in 20 (19%) patients. During test, a transient episode of a second-degree atrioventricular block and isolated ventricular ectopies were observed in 1 (0.9%) and 2 (1.9%) patients, respectively. A QRS prolongation ≥ 30% was observed in 4 (3.8%) patients. Baseline QRS duration in V1 ≥ 110 ms had a sensitivity of 70% and a specificity of 80% for a positive response. An ST-segment elevation ≥ 0.17 mV in V2 had a sensitivity of 60% and a specificity of 82% for a positive response. Of the multiple clinical and ECG variables entered into a binary logistic regression analysis, a history of syncope (P = 0.001), previous cardiac arrest (P = 0.001), baseline QRS duration in V1 ≥ 110 ms (P = 0.001), and baseline ST-segment elevation in V2 ≥ 0.17 mV (P = 0.012) emerged as the independent predictors of a positive response to the intravenous challenge with sodium channel blockers.ConclusionThe results of the sodium channel blocker challenge test can be predicted by clinical presentation and baseline ECG features.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Cardiology - Volume 165, Issue 2, 10 May 2013, Pages 285-290
نویسندگان
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