کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5978081 1576270 2011 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Lung biopsy findings in previously inoperable patients with severe pulmonary hypertension associated with congenital heart disease
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Lung biopsy findings in previously inoperable patients with severe pulmonary hypertension associated with congenital heart disease
چکیده انگلیسی

BackgroundCongenital heart disease with near-systemic pulmonary arterial pressures, previously thought to have irreversible pulmonary vascular disease (PVD), has been successfully corrected at our institution recently. Whether the PVD is reversible remains unknown. This study aimed to examine the nature of the pulmonary arterial vessels in these selective patients.MethodsAll patients with congenital heart disease and severe pulmonary hypertension (PH) were selected using Diagnostic-treatment to undergo radical repair (n = 49). Lung biopsy specimens were obtained during operation. The nature of PVD was determined by Heath-Edwards classification system. All specimens were quantitatively analyzed by calculating percentage media wall area, percentage media wall thickness and arteriole density.ResultsTranscutaneous oxygen saturation of all selected patients increased significantly after Diagnostic-treatment (P < 0.001). There were no operative deaths. Mean pulmonary artery pressure and pulmonary vascular resistance regressed significantly postoperatively (P < 0.001). The incidence of postoperative PH was 59.2% (29/49). Of 49 selected patients with severe PH, 38 (77.6%) showed grade I change, 5 (10.2%) showed grade II change, 4 (8.2%) showed grade III change and only 2 (4%) showed grade IV change with plexiform lesion. The percentage media wall area, percentage media wall thickness and arteriole density were significantly increased in patients associated with PH than in normal subjects (P < 0.001). Follow-up data showed the reversal of PVD in these 2 patients with plexiform lesions.ConclusionsThe PVD in these selective patients with congenital heart disease and severe PH using a Diagnostic-treatment-and-Repair strategy is generally reversible and these patients are operable in current era.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Cardiology - Volume 151, Issue 1, 18 August 2011, Pages 76-83
نویسندگان
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