کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5983697 1578117 2014 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A Combined-Biomarker Approach to Clinical Phenotyping Renal Dysfunction in Heart Failure
ترجمه فارسی عنوان
یک رویکرد ترکیبی بیومارکر به اختلال عملکرد کلیه فنوتیپی در نارسایی قلب
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی


- Differentiating heart failure induced vs intrinsic kidney disease is challenging.
- BNP and BUN/creatinine may help distinguish these entities.
- Renal dysfunction with low BNP and low BUN/creatinine had a good prognosis.
- Renal dysfunction with high BNP and high BUN/creatinine had a poor prognosis.

BackgroundDifferentiating heart failure (HF) induced renal dysfunction (RD) from intrinsic kidney disease is challenging. It has been demonstrated that biomarkers such as B-type natriuretic peptide (BNP) or the blood urea nitrogen to creatinine ratio (BUN/creat) can identify high- vs low-risk RD. Our objective was to determine if combining these biomarkers could further improve risk stratification and clinical phenotyping of patients with RD and HF.Methods and ResultsA total of 908 patients with a discharge diagnosis of HF were included. Median values were used to define elevated BNP (>1296 pg/mL) and BUN/creat (>17). In the group without RD, survival was similar regardless of BNP and BUN/creat (n = 430, adjusted P = .52). Similarly, in patients with both a low BNP and BUN/creat, RD was not associated with mortality (n = 250, adjusted hazard ratio [HR] = 1.0, 95% confidence interval [CI] 0.6-1.6, P = .99). However, in patients with both an elevated BNP and BUN/creat those with RD had a cardiorenal profile characterized by venous congestion, diuretic resistance, hypotension, hyponatremia, longer length of stay, greater inotrope use, and substantially worse survival compared with patients without RD (n = 249, adjusted HR = 1.8, 95% CI 1.2-2.7, P = .008, P interaction = .005).ConclusionsIn the setting of decompensated HF, the combined use of BNP and BUN/creat stratifies patients with RD into groups with significantly different clinical phenotypes and prognosis.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Cardiac Failure - Volume 20, Issue 12, December 2014, Pages 912-919
نویسندگان
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