Aminodextran polymer-functionalized reactive magnetic emulsions for potential theranostic applications

• Reactive magnetic emulsions were prepared by adsoprtion of aminodextran on iron oxide nanoparticles.
• Magnetic particles showed to be superparamagnetic.
• Prepared hybrid particles showed higher T2 contrast-hability compared to Gadolinium.
• Coated particles showed promising hyperthermia results.
• Magnetic particles have great potential in tumor theranostics applications.

Aminodextran (AMD) polymer was prepared via chemical grafting of hexamethylenediamine on oxidized dextran. Magnetic latex particles were successfully obtained by adsorption of positively charged AMD on negatively charged submicron magnetic emulsion. The adsorbed amount was found to be ranged from 20 to 1280 mg of AMD per gram of dried magnetic dispersion. The AMD-coated magnetic emulsions were characterized by positive zeta potential in the pH range from 3 to 9 compared to bare seed magnetic emulsion. All the samples showed to be superparamagnetic property, even after the adsorption of the polymer. The developed magnetic submicron particles exhibited good potential for in vivo biomedical diagnosis applications as demonstrated by their higher T2 contrast‐ability compared to Gd in magnetic resonance imaging (MRI) and hyperthermia.

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