کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
598989 1454259 2016 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Hybrid biomaterials based on calcium carbonate and polyaniline nanoparticles for application in photothermal therapy
ترجمه فارسی عنوان
مواد بیولوژیکی هیبریدی مبتنی بر کربنات کلسیم و نانوذرات پلیانیلن برای کاربرد در درمان فوتوترمال
کلمات کلیدی
کاربرد بیولوژیکی پلیمرها، بیومنریالیزاسیون، سیستم های تحویل دارو، نانوکامپوزیت ها، نانوذرات
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی شیمی کلوئیدی و سطحی
چکیده انگلیسی


• Novel hybrid nanomaterial composed by calcium carbonate and polyaniline was synthesized and characterized.
• The new hybrid nanomaterial could be efficiently used in photothermal therapy (PTT).
• The first experimental demonstration of this nanomaterial applying in PTT was described.
• A controlled-phototermal cytotoxic effect can be utilized after irradiation in vitro.

Inorganic materials contain remarkable properties for drug delivery, such as a large surface area and nanoporous structure. Among these materials, CaCO3 microparticles (CMPs) exhibit a high encapsulation efficiency and solubility in acidic media. The extracellular pH of tumor neoplastic tissue is significantly lower than the extracellular pH of normal tissue facilitating the release of drug-encapsulating CMPs in this area. Conducting polyaniline (PANI) absorbs light energy and transforms it into localized heat to produce cell death. This work aimed to generate hybrid CMPs loaded with PANI for photothermal therapy (PTT). The hybrid nanomaterial was synthesized with CaCO3 and carboxymethyl cellulose in a simple, reproducible manner. The CMP-PANI-Cys particles were developed for the first time and represent a novel type of hybrid biomaterial. Resultant nanoparticles were characterized utilizing scanning electron microscopy, dynamic light scattering, zeta potential, UV–vis, FTIR and Raman spectroscopy. In vitro HeLa cells in dark and irradiated conditions showed that CMP-PANI-Cys and PANI-Cys are nontoxic at the assayed concentrations. Hybrid biomaterials displayed high efficiency for potential PTT compared with PANI-Cys. In summary, hierarchical hybrid biomaterials composed of CMPs and PANI-Cys combined with near infrared irradiation represents a useful alternative in PTT.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Colloids and Surfaces B: Biointerfaces - Volume 145, 1 September 2016, Pages 634–642
نویسندگان
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