کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
599049 | 1454261 | 2016 | 8 صفحه PDF | دانلود رایگان |
• Micelles loaded with two types of drugs could be constructed by one-pot strategy.
• The boronate ester endows micelles with pH-responsive drug release behavior.
• The drug loaded micelles could show synergistic efficacy against cancer cells.
• The reported strategy is achievable, effortless and expandable.
In this study, one-pot strategy for the construction of micelles loaded with two types of anticancer drugs (i.e., doxorubicin and methotrexate) together is reported. On the basis of the reaction between boronic acid and 1,2-diol to form boronate ester, the formation of amphiphiles, their self-assembly into micelles and drug encapsulation occurs simultaneously under simple dialysis at the appropriate pH condition. In the one-pot strategy, the micelle yield is high (78.2%) and the drug encapsulation efficiency of the two drugs is improved compared with that of the traditional method. The micelles can selectively increase the drug release ratio at acidic pH, showing the pH-responsive behavior inherited from the property of boronate ester. By combining doxorubicin and methotrexate, the half-maximum inhibition concentrations of the two drugs are obviously reduced, showing synergistic efficacy against cancer cells. This strategy is promising and may be expanded to various applications.
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Journal: Colloids and Surfaces B: Biointerfaces - Volume 143, 1 July 2016, Pages 285–292