کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
599120 1454264 2016 7 صفحه PDF سفارش دهید دانلود رایگان
عنوان انگلیسی مقاله ISI
Solid lipid nanoparticles for encapsulation of hydrophilic drugs by an organic solvent free double emulsion technique
ترجمه فارسی عنوان
نانوذرات لیپید جامد برای کپسوله کردن داروهای هیدروفیلی با تکنیک دوام امولسیون حلال آلی
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کلمات کلیدی
نانوذرات لیپید جامد، دوز امولسیون آزاد حلال الی، سیستم های تحویل، ترکیبات هیدروفیلی، بازده انعقادی
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی شیمی کلوئیدی و سطحی
چکیده انگلیسی


• Solid lipid nanoparticles (SLN) were prepared by a novel organic solvent free double emulsion/melt dispersion technique.
• SLN size can be easily controlled by surfactant choice and concentration.
• It is a robust technique for encapsulation of hydrophilic and lipophilic compounds.
• The SLN present a high potential for application as delivery systems.

Encapsulation of hydrophilic compounds for drug delivery systems with high loading efficiency is not easily feasible and remains a challenge, mainly due to the leaking of the drug to the outer aqueous phase during nanoparticle production. Usually, encapsulation of hydrophilic drugs is achieved by using double emulsion or inverse miniemulsion systems that often require the use of organic solvents, which may generate toxicological issues arising from solvent residues. Herein, we present the preparation of solid lipid nanoparticles loaded with a hydrophilic compound by a novel organic solvent free double emulsion/melt dispersion technique. The main objective of this study was to investigate the influence of important process and formulation variables, such as lipid composition, surfactant type, sonication parameters and lipid solidification conditions over physicochemical characteristics of SLN dispersion. Particle size and dispersity, as well as dispersion stability were used as responses. SLN dispersions with average size ranging from 277 to 550 nm were obtained, showing stability for over 60 days at 4 °C depending on the chosen emulsifying system. Entrapment efficiency of fluorescent dyes used as model markers was assessed by fluorescence microscopy and UV–vis spectrophotometry and results suggest that the obtained lipid based nanoparticles could be potentially applied as a delivery system of water soluble drugs.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Colloids and Surfaces B: Biointerfaces - Volume 140, 1 April 2016, Pages 317–323
نویسندگان
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