کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
599130 1454264 2016 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Topologically controlled hyaluronan-based gel coatings of hydrophobic grid-like scaffolds to modulate drug delivery
ترجمه فارسی عنوان
پوشش های ژل مبتنی بر هیپوالورونان تحت تاکید از داربست های شبکهای هیدروفوب به منظور تعدیل تحویل دارو
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی شیمی کلوئیدی و سطحی
چکیده انگلیسی


• Poly(ethyl acrylate) grid-like scaffolds were coated with hyaluronan (HA) gel.
• Controlled coating typologies were obtained by varying the HA concentration.
• Mechanical properties and swelling were correlated with the HA mass fraction.
• Their potential as drug release vehicle was proven using a protein model.

Scaffolds based on poly(ethyl acrylate) having interwoven channels were coated with a hyaluronan (HA) hydrogel to be used in tissue engineering applications. Controlled typologies of coatings evolving from isolated aggregates to continuous layers, which eventually clog the channels, were obtained by using hyaluronan solutions of different concentrations. The efficiency of the HA loading was determined using gravimetric and thermogravimetric methods, and the hydrogel loss during the subsequent crosslinking process was quantified, seeming to depend on the mass fraction of hyaluronan initially incorporated to the pores. The effect of the topologically different coatings on the scaffolds, in terms of mechanical properties and swelling at equilibrium under different conditions was evaluated and correlated with the hyaluronan mass fraction. The potential of these hydrogel coatings as vehicle for controlled drug release from the scaffolds was validated using a protein model.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Colloids and Surfaces B: Biointerfaces - Volume 140, 1 April 2016, Pages 412–420
نویسندگان
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