Wheat germ agglutinin anchored chitosan microspheres of reduced brominated derivative of noscapine ameliorated acute inflammation in experimental colitis

- Brominated derivative of noscapine (Red-Br-Nos, EM012) has potent anti-inflammatory property against colitis.
- Wheat germ agglutinin anchored chitosan microspheres offered controlled release of Red-Br-Nos in simulated colonic fluid with colitis milieu, in vitro.
- Superior bioadhesive property of wheat germ agglutinin anchored microspheres of Red-Br-Nos ameliorated inflammation in experimental colitis.