Strategies of polymeric nanoparticles for enhanced internalization in cancer therapy

- Targeting ligands enhance internalization of polymeric nanoparticles in cancer cells.
- TAT is exposed by shield/deshielding mechanism to avoid non-specific binding.
- Tumor pH actives ligand-mediated delivery for tumor targeting.
- Tumor pH triggers charge conversion to tumor cell uptake.
- Polymeric nanoparticles have the potential to overcome resistance.