کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
599357 1454270 2015 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Enhanced topical delivery of hyaluronic acid encapsulated in liposomes: A surface-dependent phenomenon
ترجمه فارسی عنوان
تحویل موضعی پیشرفته اسید هیالورونیک بسته بندی شده در لیپوزوم: پدیده وابسته به سطح
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی شیمی کلوئیدی و سطحی
چکیده انگلیسی


• Hyaluronic acid encapsulated in liposomes shows increased bioavailability for topical application.
• Penetration enhancers incorporated modify the permeation of HA in cellulose and human skin.
• Structures onto surfaces were observed by AFM.
• Adhesion forces were measured by AFM-Force volume mode.
• Multilayer lipid structures and permeation process seem to be related.

In the present study, we investigated the release and permeation of hyaluronic acid (HA) encapsulated in liposomes when deposited onto two surfaces: cellulose, a model widely used for investigating transport of drugs; and human skin, a natural biointerface used for transdermal drug delivery. We prepared and characterised liposomes loaded with HA and liposomes incorporating two penetration enhancers (PEs): the non-ionic surfactant Tween® 80, and Transcutol® P, a solubilising agent able to mix with polar and non-polar solvents. In vitro and ex vivo permeation assays showed that PEs indeed enhance HA-release from liposomes. Since one of the possible mechanisms postulated for the action of liposomes on skin is related to its adsorption onto the stratum corneum (SC), we used atomic force microscopy (AFM) topography and force volume (FV) analysis to investigate the structures formed after deposition of liposome formulations onto the investigated surfaces. We explored the possible relationship between the formation of planar lipid structures on the surfaces and the permeation of HA.

Liposomes containing HA formed SLBs onto the human skin were HA is mainly liberated in the epidermis.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Colloids and Surfaces B: Biointerfaces - Volume 134, 1 October 2015, Pages 31–39
نویسندگان
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