Reduction-sensitive micelles with sheddable PEG shells self-assembled from a Y-shaped amphiphilic polymer for intracellular doxorubicine release

- A Y-shaped amphiphilic reduction-sensitive polymer [mPEG-S-S-(PCL)2] was developed.
- The polymer could self-assemble into micelles and encapsulate DOX.
- The PEG shell of these micelles could be shed in the presence of reducing agent.
- The DOX-loaded micelles exhibited faster DOX release in GSH-OEt-pretreated cells.