Redox and pH-responsive poly (amidoamine) dendrimer-poly (ethylene glycol) conjugates with disulfide linkages for efficient intracellular drug release

- Redox and pH sensitive PAMAM-SS-PEG conjugates were synthesized by a simple process.
- Conjugates exhibited excellent stability and effectively diminished uptake by RES.
- Drug release from the conjugates was followed a reduction and pH-triggered pattern.
- DOX-loaded conjugates showed significant cytotoxicity against B16 and A549 cells.