Liposomes as carriers of hydrophilic small molecule drugs: Strategies to enhance encapsulation and delivery

- Many hydrophilic small molecule drugs undergo suboptimal encapsulation and delivery.
- We review liposomal loading of hydrophilic small molecule drugs.
- Lipid composition, drug/lipid ratio, charge and loading method affect encapsulation.
- Liposomal targeted and triggered delivery enhance efficacy of hydrophilic drugs.